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Showing posts with the label hypertrophic cardiomyopathy

Negative screening for HCM in Maine Coon kittens does not rule out the disease

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In layperson's terms, we know that it's possible to screen Maine Coon breeding cats, foundation cats and the parents of kittens plus the kittens created at cat breeders for hypertrophic cardiomyopathy in order to prevent the creation of Maine Coon cats who are predisposed to hypertrophic cardiomyopathy (HCM) and therefore to reassure purchasers of purebred Maine Coon cats that their purchase will not show signs of the disease quite soon after purchase and have a shortened lifespan as a consequence. By 'screening' I mean testing for a mutant gene that causes the disease. When a Maine Coon breeder says that they screen their cats and kittens for the disease that they sell to clients, should a negative test result totally reassure the client that their purchased kitten will not develop HCM? That is the $64,000 question. The answer to that question is clearly NO , sadly. My research clearly indicates that a Maine Coon cat screened as negative for HCM may still develop this...

Earliest age when HCM in Maine Coons can be detected

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Beautiful Maine Coon ginger tabby kitten but are they predisposed to HCM? Image: Photo: Viktoria Vyacheslavovna Terskaya. My research using clinical studies informs me that the disease usually appears around 6 months of age but perhaps as early as 3 months of age according to one American hospital. ---------------- The first study I looked at describes the development and characteristics of a colony of Maine coon cats that had familial hypertrophic cardiomyopathy (FHCM), a genetic heart disease. The researchers bred affected and unaffected cats to determine the mode of inheritance of the disease and used echocardiography to identify affected offspring and determine the natural history of the disease.  The results showed that the disease follows an autosomal dominant pattern of inheritance with 100% penetrance, meaning that individuals who carry the genetic mutation for the disease will develop it. The disease usually appears in cats around 6 months of age and becomes more severe i...

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