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Mode of inheritance of spinal muscular atrophy in Maine Coon cats

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You may have heard of spinal muscular atrophy (SMA) in Maine Coon cats. It is one of those inherited diseases, several of which affect the Maine Coon, and as indicated in the title the muscles of the back become weakened which interferes with their normal activities such as jumping and walking.  These are not Maine Coons. Image in the public domain (believed). The cause is due to a loss of neurons in the first few weeks of life. The weakness becomes apparent at 3-4 months of age. Kittens walk with a strange gait and their hocks nearly touch the ground. The hock is the area from the end of the foot to the first part of the leg. RELATED: 15 facts about spinal muscular atrophy in Maine Coon cats. There should be no difficulty in diagnosing SMA being present in a Maine Coon cat. The disease is inherited as an autosomal (non-sex-linked) recessive mutated genetic trait. Genes come in pairs. If a Maine Coon cat has one copy of the mutated gene and one copy without the mutation they are re...
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Is spinal muscular atrophy (SMA) in Maine Coon cats painful?

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Answer to the title question:  While SMA can cause discomfort and weakness, it is not typically considered a painful condition in cats  (source: ChatGPT) .  That does not say it does not cause pain. It does say that it causes discomfort which is a mild form of pain isn't it?! This is one of several inherited diseases linked to this cat breed, all of which cause discomfort to varying degrees. Hip dysplasia simply causes pain, bad pain I'd suggest as it causes arthritis - bone on bone. There is a question mark over whether it is cruel to breed this cat under the current circumstances as managed by the cat associations .  They accept these problems. They should not. It is unethical to continue breeding cats like this. Note: UC Davis in the US have a DNA test for this disease. Affected by SMA. Image in public domain believed. RELATED: the above picture accompanies a page on 15 facts about this disease -  LINK . Spinal muscular atrophy (SMA) is a genetic disorder tha...
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15 facts about spinal muscular atrophy in Maine Coon cats

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Here are 15 facts about spinal muscular atrophy (SMA) in Maine Coon cats. SMA in a young non-Maine Coon. Image believed to be in the public domain and from a study: "Failure of lower motor neuron radial outgrowth precedes retrograde degeneration in a feline model of spinal muscular atrophy." SMA is an inherited genetic disease in Maine Coon cats causing a decreased muscle mass. If two carrier cats, that is cats which are heterozygous to the disease which means they carry one copy of the gene mutation, are mated there is a 25% probability of the offspring being affected. This means that 25% of the offspring will be homozygous to the disease which in turn means that they have two copies of the gene mutation. The disease will be present in them. The disease affects the spinal cord nerves that control the skeletal muscles of the body and legs. The spinal cord nerves die off. The disease is evident at about 3 to 4 months of age. Kittens move with a sway in the rear end. By the ag...
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Spinal Muscular Atrophy in Maine Coon Cats

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This genetically inherited disease in Maine Coon cat needs to be discussed but I don't want to paint an unnecessarily negative picture about this wonderful and popular cat breed. The best book on cat health problems ( Cat Owner's Home Veterinary Handbook ) says on page 345 (latest edition at the date of this post) that this is "a genetic defect in Maine Coon cats". Cute ginger tabby MC sitting on his backside. Image in the public domain (believed). Spinal nerves die off that control the "skeletal muscles". The disease is evident at 3-4 months of age. The rear end of the cat sways and at about 5 months of age the cat cannot jump. There appears to be no pain and there is no treatment. The muscles decrease in size. A DNA test has been developed at the Laboratory of Comparative Medical Genetics at Michigan State University. Maine Coon cat owners send a cheek swab to the testing center to see if they are carriers before being bred. This is clearly a service for...
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The extreme Maine Coon face

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This is an example of extreme breeding. This is a Maine Coon but this cat is an extreme and rare example of this breed. This is not the way they look normally. This face is almost like an aggressive robot with the piercing eyes and the huge muzzle.  Or like a lion's head. The head looks enormous and very heavy. It looks unreal. But it also looks very impressive.  And purchasers like impressive-looking domestic cats. But this not the face of a Maine Coon that wins cat show competitions as it does not fit the breed standard as accurately as the more moderate winners (see below).  In fact, the CFA standard is clear in that the cat should have a balanced appearance although this cat was not bred under the CFA breed standard as I understand it (see below).  Click here for more on the kind of MC which wins at shows . Maine Coon selectively breed to have an extreme face. Image in the public domain. And the Maine Coon is meant to be a large cat, the largest domestic cat b...
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Maine Coon Size - this is a huge one!

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  Enormous Maine Coon with a head bigger than the person holding him. Pic: in public domain. Maine Coon size is very important to both breeders of this cat and the public. I sometimes think that the public is more obsessed with Maine Coon size than the breeders are. The bigger the Maine Coon the better. There is a fascination about it and I confess that there is nothing much more impressive than a huge Maine Coon. They've been bred like this through selective breeding but please remember that they weren't always like this. The original Maine Coons were regular farm cats in the state of Maine in 19th-century and before. They were robust, rugged, medium-longhaired moggy cats but impressive nonetheless. Their impressiveness led to breeders deciding to breed them which in turn led to the breed being accepted by the cat associations and then to win cat shows and become perhaps one of the most famous breeds in the world. The breed standard for the Maine Coon as provided by e.g. Cat F...
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Comparison of a black smoke Maine Coon at 6 weeks and 6-years-of-age

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This is a cross-post as the image is so damned good. It is amazing because the cat is amazing. To put the same cat at different stages of their life in the same photograph is a nice idea especially with this Maine Coon (MC) who has an amazingly heavy face. It is so mightily masculine to be almost unbelievable. He has a priceless expression on his face too. Very serious compared to the innocence of his face when he was 6 weeks old. He looks a bit coy when 6 weeks old and a slightly grumpy middle-aged man when 6 years old. Comparison of a black smoke Maine Coon at 6-weeks and 6-years-of-age. Image in pubic domain. No doubt he is huge too. You get a clear sense of that in the image. There is a serious and less impressive side to this image. It's the backstory that people don't really want to read about and discuss or in fact do anything about: heart ( HCM ) and joint disease. The bigger and heavier the MCs are the more predisposed to heart disease they are. Here is the posts on...
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Average lifespan of Maine Coon cat

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How long do Maine Coon cats live for? What's the average lifespan? Do they live shorter lives than the average random-bred family cat? These are difficult questions to answer accurately. In fact, I don't think we can answer them accurately because nobody has been counting. Nobody has a database or carried out a full-blown survey and therefore you will read anecdotal evidence i.e. statements by breeders or people who think they know the answer and these answers get repeated on the Internet. I am not sure that they are accurate. Picture of a Maine Coon who looks like a middle-aged man. Photo: Pinterest. My research indicates that people believe that Maine Coon cats live between about 10 and 15 years old. Some may live longer than that and some may live shorter lives. One well-known Maine Coon, Rubble, lived for 31 years and was at one time the oldest domestic cat in the world. But there will always be exceptions and this article is about the mean or the average although these ...
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Eerie picture of a Maine Coon sitting like a human on a chest of drawers

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This is a slightly scary picture according to those who've seen it. One social media user said it was the devil and "If I walked into a room and saw that, I would assume some shit is about to go down". There is a ghostly stillness and sinister feeling about the image. 'Eerie' is a better description. This attractive cat appears to be completely at ease and comfortable sitting on top of a chest of bedroom drawers. The lighting from below (deliberate?) enhances the eerie effect. It seems possible that this is a photo-edited image but if so, it has been done with great skill. However, I don't think this is Photoshopped. Rethink: to be honest, the more I look at the picture, the more I feel that this is a photo-edited image. It is just too unnatural to be real. Although some domestic cats get themselves into some very strange positions. Maine Coon calmly sitting just like a human on a chest of drawers. Picture source unclear. Image deemed to be in the public d...
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Tortoiseshell Maine Coon with split-face

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Maine Coon with "split face". Photo: Screenshot. This is a very impressive Maine Coon. As you can see she is a tortoiseshell and as you probably know almost all tortoiseshell and calico cats are female. There are a few male tortoiseshell cats (and this might be one of them). Their sex is caused by a genetic aberration because the genetics of tortoiseshell cats dictates that they are almost always female. About one in 3000 are male as I recall. Also, it is not that unusual to see this extreme pattern on the face which creates the appearance of a "split-face". This is not what is called a "chimera" but a normal variation of the tortoiseshell pattern. Sometimes you do see what some people call "two-faced" cats with this sort of face due to a sharply defined pattern down the middle of the face. But the genetics behind that is different to this normal tortoiseshell variation. This is a particularly extraordinary looking Maine Coon cat. Not all Maine C...
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Are Maine Coons illegal in some countries, states or territories?

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One Maine Coon website asks if Maine Coons are legal? My initial response was that it is a bizarre question (second thoughts below), but I'll answer it in my way. I say that it is a bizarre question because the Maine Coon is an entirely domestic cat by which I mean NOT a wild cat hybrid and therefore there is no reason whatsoever to declare it illegal in any jurisdiction unless that there is some other fanciful reason to ban the cat (there might be - see below). Are Maine Coons illegal in some countries, states or territories? No, to the best of my knowledge. Image: MikeB I know of no jurisdiction anywhere in the world that bans Maine Coons which makes sense. Conversely a similar sized domestic cat, the F1-F2 Savannah, is illegal in many jurisdictions (states, territories and countries) because it is a wildcat hybrid. The cat has some wild cat DNA which some legislatures consider to be detrimental to human health and welfare and to the conservation of wildlife (if the cat escapes t...
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Difference between Maine Coon and domestic long hair

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The difference between a Maine Coon cat and a domestic longhaired cat comes down to the fact that the former has been artificially bred (selective breeding) whereas the latter has usually procreated according to natural selection. Natural selection is random breeding and therefore the domestic longhair is a random-bred cat whereas, selective breeding produces a purebred, pedigree cat registered with a cat association.  Difference between Maine Coon and domestic long hair. Infographic by MikeB. And because each individual Maine Coon cat is registered with a cat association, if they are in genuine Maine Coon, their appearance should comply with the association's breed standard . The breed standard tells breeders what their Maine Coon cats should look like in order that they can win cat show competitions if they want to enter their cat into these competitions. And so, as the appearance of Maine Coon cats is moulded to the guidance of a breed standard (see a section below from the...
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No part of a Maine Coon cat should be exaggerated

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It is interesting to read that the premier cat association, the CFA (Cat Fanciers' Association) - the cat association which really dictates (with TICA) how Maine Coons should look - makes it clear that no part of the cat should be exaggerated, and the cat should be "well-proportioned and balanced".  In other words, any form of extreme appearance such as a particularly heavy muzzle or particularly large ears with extra-long lynx tips are not going to be seen as advantageous in terms of winning cat shows or in terms of having an ideal appearance. As soon as I read that no part of a Maine Coon should be exaggerated, I immediately thought of the extremely large, extreme-bred Maine Coon cats that often come from Russia. These cats have very heavy muzzles.  Lion-faced Maine Coon with exaggerated features. Image in public domain now. In fact, their heads look like the heads of lions. I get the impression that breeders have selectively bred their cats over years to look like male...
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2 top Russian Maine Coon cat breeders which ship internationally

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I am writing this from the West; specifically, near London, UK. There will be quite a few people living in the West who'd like to adopt a Maine Coon cat and they would like to adopt one from a Russian breeder because they do have a certain style.  I sense, although I don't have hard evidence to support this feeling, that the top Russian breeders of Maine Coon cats might be superior to breeders from other countries.  I am putting aside Putin's invasion of Ukraine when writing this article. Some people might object to dealing in anyway with a Russian business on account of that barbaric and illegal invasion. We should remember that Russia has quite a strong cat fancy. They like their cats and they love their purebred cats particularly the Maine Coon. It is in fact a cat breed which is quite naturally suited to the Russian way of life and climate. There's lots of space in Russia with a relatively low population and therefore there are going to be houses with large grounds ...
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